Yes, this non-nutritive sweetener has been approved as a safe ingredient by the U.S. Food and Drug Administration (FDA) and European Food Safety Authority (EFSA), as well as Joint FAO/WHO Expert Committee on Food Additives (JECFA).   

FDA
Neotame may be safely used as a sweetener and flavor enhancer in food (2). The ADI is 0.3mg/kg bw/d. (3)

EFSA
Neotame (E961) is listed in Commission Regulation (EU) No 231/2012 as an authorised food additive and categorized in “Sweeteners” (4).

Safety re-evaluation in 2007
After the studies of genotoxicity, carcinogenicity, teratogenicity, reproductive and developmental toxicity, along with the degradation products researches, EFSA concluded it was not of safety concern when neotame is intended to be used as a sweetener and flavour enhancer and an Acceptable Daily Intake (ADI) of 0-2 mg/kg bw/day was established. (5)

Approved uses
When used as a sweetener, neotame is commonly used in energy-reduced or no-added-sugar products with the maximum usage ranges from 2-200mg/kg; or the use levels are “quantum satis” in table-top sweeteners in liquid/powder/tablets.
When used as a flavour enhancer, its maximum usage is 2mg/kg. (6)
UK Food Standards Agency
Categorized in “Sweeteners” (7)

Food Standards Australia New Zealand

It is approved ingredient in Australia and New Zealand with the code number 961. (8)

JECFA
Function Class: food additives, sweetener, flavor enhancer. (9)

Acceptable daily intake: ADI “0-2mg/kg bw” set in 2003. (10)

http://www.chinafooding.com/Neotame