Folic acid supplement can not abuse
1), long-term pregnant mothers taking folic acid can interfere with zinc metabolism, zinc intake once, it will affect fetal development.

2), pregnant mothers preferably under the guidance of a doctor taking folic acid preparations.
3), who has had neural tube defects in babies born of women, pregnant again, the best to the hospital, and was prescribed folic acid daily dose increase until 12 weeks after pregnancy.
4), pre-pregnancy long term use of contraceptives, anticonvulsants, may interfere with the metabolism of folate and other vitamins. Women planning a pregnancy is best to stop the medication for six months before pregnancy, and folic acid and other vitamins.

Overexpression
Folic acid is a water-soluble vitamin, generally exceed 20 times the minimum requirement for adults does not cause poisoning. All serum and tissue beyond the combination of volume and peptides from urine. Taking large doses of folic acid may produce toxic effects are:
1. Interfere with the role of anticonvulsant drugs, patients induced seizures.
2. 350mg of oral folic acid may affect the absorption of zinc, and lead to zinc deficiency, fetal growth retardation, low birth weight children increased.
3. Mask early signs of vitamin B12 deficiency, which led to nervous system damage.